AADC is a genetically inherited neurological disorder affecting the brains ability to produce neurotransmitters, dopamine and serotonin; two of the most essential neurotransmitters needed for every day living!

AADC deficiency presents early in life with hypotonia, hypokinesia, Oculogyric Crisis (known as a spell/attack), autonomic dysfunction, dysphoric mood, and sleep disturbance.

Affected children can also show a number of movement disorders, most frequently dystonia. Diurnal fluctuation and improvement of symptoms after sleep is a characteristic of AADC.

The severity of symptoms experienced by each affected child varies, but the majority of children show minimal motor development in the absence of treatment.

Please explore the links under 'Understanding AADC' to find out more about the disease.